WNT Signaling

No Pathway Network information available for WNT Signaling

Pathways in the WNT Signaling SuperPath

#	Name	Source	Genes
1	WNT Signaling	QIAGEN	APC ATF4 AXIN1 BCL9 BIRC5 BTRC CAMK2A CAMK2B CAMK2D CAMK2G CBY1 CCND1 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 CDH2 CDH20 CDH22 CDH23 CDH24 CDH26 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CEBPB CER1 CHUK CLDN1 CREB1 CREB3 CREB3L4 CREBBP CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CTNNA1 CTNNB1 DAAM1 DAAM2 DCHS1 DKK1 DKK2 DKK4 DVL1 ENC1 FOSL1 FRZB FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GAST GCFC2 GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GSK3B HNF1A HNF1B HNF4A JUN KREMEN1 KREMEN2 LEF1 LRP5 LRP6 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 MAP3K9 MAPK10 MAPK8 MAPK9 MMP7 MYC NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFE2L1 NRCAM PLAUR PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PPARD PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PTGS2 PYGO1 PYGO2 RAC1 REST RHOA ROCK2 SMARCA4 TCF12 TCF15 TCF19 TCF20 TCF21 TCF23 TCF3 TCF4 TCF7 TCF7L2 TEAD1 TEAD4 TFAM TP53 UBB UBC UBD UBE2D2 VIM WIF1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B ZEB1 ZNF354A (see all 250) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
2	RHOA	Ras Homolog Family Member A	Protein Coding	1
3	ATF4	Activating Transcription Factor 4	Protein Coding	1
4	AXIN1	Axin 1	Protein Coding	1
5	BCL9	BCL9 Transcription Coactivator	Protein Coding	1
6	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
7	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
8	CBY1	Chibby 1, Beta Catenin Antagonist	Protein Coding	1
9	GCFC2	GC-Rich Sequence DNA-Binding Factor 2	Protein Coding	1
10	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
11	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
12	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
13	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
14	CCND1	Cyclin D1	Protein Coding	1
15	CDH1	Cadherin 1	Protein Coding	1
16	CDH10	Cadherin 10	Protein Coding	1
17	CDH11	Cadherin 11	Protein Coding	1
18	CDH12	Cadherin 12	Protein Coding	1
19	CDH13	Cadherin 13	Protein Coding	1
20	CDH15	Cadherin 15	Protein Coding	1
21	CDH16	Cadherin 16	Protein Coding	1
22	CDH17	Cadherin 17	Protein Coding	1
23	CDH18	Cadherin 18	Protein Coding	1
24	CDH19	Cadherin 19	Protein Coding	1
25	CDH2	Cadherin 2	Protein Coding	1
26	CDH20	Cadherin 20	Protein Coding	1
27	CDH22	Cadherin 22	Protein Coding	1
28	CDH23	Cadherin Related 23	Protein Coding	1
29	CDH24	Cadherin 24	Protein Coding	1
30	CDH26	Cadherin 26	Protein Coding	1
31	CDH3	Cadherin 3	Protein Coding	1
32	CDH4	Cadherin 4	Protein Coding	1
33	CDH5	Cadherin 5	Protein Coding	1
34	CDH6	Cadherin 6	Protein Coding	1
35	CDH7	Cadherin 7	Protein Coding	1
36	CDH8	Cadherin 8	Protein Coding	1
37	CDH9	Cadherin 9	Protein Coding	1
38	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
39	CER1	Cerberus 1, DAN Family BMP Antagonist	Protein Coding	1
40	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
41	CLDN1	Claudin 1	Protein Coding	1
42	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
43	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
44	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
45	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
46	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
47	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1
48	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
49	CSNK1G1	Casein Kinase 1 Gamma 1	Protein Coding	1
50	CSNK1G2	Casein Kinase 1 Gamma 2	Protein Coding	1
51	CSNK1G3	Casein Kinase 1 Gamma 3	Protein Coding	1
52	CTNNA1	Catenin Alpha 1	Protein Coding	1
53	CTNNB1	Catenin Beta 1	Protein Coding	1
54	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	1
55	DAAM2	Dishevelled Associated Activator Of Morphogenesis 2	Protein Coding	1
56	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
57	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1
58	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
59	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
60	ENC1	Ectodermal-Neural Cortex 1	Protein Coding	1
61	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
62	FRZB	Frizzled Related Protein	Protein Coding	1
63	FZD1	Frizzled Class Receptor 1	Protein Coding	1
64	FZD10	Frizzled Class Receptor 10	Protein Coding	1
65	FZD2	Frizzled Class Receptor 2	Protein Coding	1
66	FZD3	Frizzled Class Receptor 3	Protein Coding	1
67	FZD4	Frizzled Class Receptor 4	Protein Coding	1
68	FZD5	Frizzled Class Receptor 5	Protein Coding	1
69	FZD6	Frizzled Class Receptor 6	Protein Coding	1
70	FZD7	Frizzled Class Receptor 7	Protein Coding	1
71	FZD8	Frizzled Class Receptor 8	Protein Coding	1
72	FZD9	Frizzled Class Receptor 9	Protein Coding	1
73	GAST	Gastrin	Protein Coding	1
74	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
75	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
76	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
77	GNA14	G Protein Subunit Alpha 14	Protein Coding	1
78	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
79	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
80	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
81	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
82	GNAL	G Protein Subunit Alpha L	Protein Coding	1
83	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
84	GNAS	GNAS Complex Locus	Protein Coding	1
85	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	1
86	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	1
87	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
88	GNB1	G Protein Subunit Beta 1	Protein Coding	1
89	GNB2	G Protein Subunit Beta 2	Protein Coding	1
90	GNB3	G Protein Subunit Beta 3	Protein Coding	1
91	GNB4	G Protein Subunit Beta 4	Protein Coding	1
92	GNB5	G Protein Subunit Beta 5	Protein Coding	1
93	GNG10	G Protein Subunit Gamma 10	Protein Coding	1
94	GNG11	G Protein Subunit Gamma 11	Protein Coding	1
95	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
96	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
97	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
98	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
99	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
100	GNG5	G Protein Subunit Gamma 5	Protein Coding	1
101	GNG7	G Protein Subunit Gamma 7	Protein Coding	1
102	GNG8	G Protein Subunit Gamma 8	Protein Coding	1
103	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
104	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	1
105	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
106	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
107	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
108	KREMEN1	Kringle Containing Transmembrane Protein 1	Protein Coding	1
109	KREMEN2	Kringle Containing Transmembrane Protein 2	Protein Coding	1
110	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
111	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
112	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
113	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
114	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
115	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
116	MAP3K10	Mitogen-Activated Protein Kinase Kinase Kinase 10	Protein Coding	1
117	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
118	MAP3K12	Mitogen-Activated Protein Kinase Kinase Kinase 12	Protein Coding	1
119	MAP3K13	Mitogen-Activated Protein Kinase Kinase Kinase 13	Protein Coding	1
120	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
121	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
122	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
123	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
124	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
125	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
126	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
127	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
128	MAP3K9	Mitogen-Activated Protein Kinase Kinase Kinase 9	Protein Coding	1
129	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
130	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
131	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
132	MMP7	Matrix Metallopeptidase 7	Protein Coding	1
133	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
134	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	1
135	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
136	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
137	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
138	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
139	NFE2L1	NFE2 Like BZIP Transcription Factor 1	Protein Coding	1
140	NRCAM	Neuronal Cell Adhesion Molecule	Protein Coding	1
141	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1
142	DCHS1	Dachsous Cadherin-Related 1	Protein Coding	1
143	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
144	PLCB1	Phospholipase C Beta 1	Protein Coding	1
145	PLCB2	Phospholipase C Beta 2	Protein Coding	1
146	PLCB3	Phospholipase C Beta 3	Protein Coding	1
147	PLCB4	Phospholipase C Beta 4	Protein Coding	1
148	PLCD1	Phospholipase C Delta 1	Protein Coding	1
149	PLCD3	Phospholipase C Delta 3	Protein Coding	1
150	PLCD4	Phospholipase C Delta 4	Protein Coding	1
151	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
152	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
153	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
154	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
155	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
156	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
157	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
158	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
159	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
160	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
161	PRKCA	Protein Kinase C Alpha	Protein Coding	1
162	PRKCB	Protein Kinase C Beta	Protein Coding	1
163	PRKCD	Protein Kinase C Delta	Protein Coding	1
164	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
165	PRKCG	Protein Kinase C Gamma	Protein Coding	1
166	PRKCH	Protein Kinase C Eta	Protein Coding	1
167	PRKCI	Protein Kinase C Iota	Protein Coding	1
168	PRKD1	Protein Kinase D1	Protein Coding	1
169	PRKD3	Protein Kinase D3	Protein Coding	1
170	PRKCQ	Protein Kinase C Theta	Protein Coding	1
171	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
172	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
173	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
174	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
175	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
176	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
177	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
178	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
179	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
180	PSMB10	Proteasome 20S Subunit Beta 10	Protein Coding	1
181	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
182	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
183	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
184	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
185	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
186	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
187	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	1
188	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	1
189	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
190	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
191	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
192	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
193	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
194	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
195	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
196	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
197	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
198	PSMD4	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4	Protein Coding	1
199	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	1
200	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	1
201	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
202	PYGO1	Pygopus Family PHD Finger 1	Protein Coding	1
203	PYGO2	Pygopus Family PHD Finger 2	Protein Coding	1
204	RAC1	Rac Family Small GTPase 1	Protein Coding	1
205	REST	RE1 Silencing Transcription Factor	Protein Coding	1
206	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
207	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
208	HNF1A	HNF1 Homeobox A	Protein Coding	1
209	TCF12	Transcription Factor 12	Protein Coding	1
210	TCF15	Transcription Factor 15	Protein Coding	1
211	TCF19	Transcription Factor 19	Protein Coding	1
212	HNF1B	HNF1 Homeobox B	Protein Coding	1
213	TCF20	Transcription Factor 20	Protein Coding	1
214	TCF21	Transcription Factor 21	Protein Coding	1
215	TCF23	Transcription Factor 23	Protein Coding	1
216	TCF3	Transcription Factor 3	Protein Coding	1
217	TCF4	Transcription Factor 4	Protein Coding	1
218	TCF7	Transcription Factor 7	Protein Coding	1
219	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
220	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	1
221	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	1
222	TEAD4	TEA Domain Transcription Factor 4	Protein Coding	1
223	TFAM	Transcription Factor A, Mitochondrial	Protein Coding	1
224	TP53	Tumor Protein P53	Protein Coding	1
225	UBB	Ubiquitin B	Protein Coding	1
226	UBC	Ubiquitin C	Protein Coding	1
227	UBD	Ubiquitin Like Modifier D	Protein Coding	1
228	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	1
229	VIM	Vimentin	Protein Coding	1
230	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
231	WNT1	Wnt Family Member 1	Protein Coding	1
232	WNT10A	Wnt Family Member 10A	Protein Coding	1
233	WNT10B	Wnt Family Member 10B	Protein Coding	1
234	WNT11	Wnt Family Member 11	Protein Coding	1
235	WNT9A	Wnt Family Member 9A	Protein Coding	1
236	WNT9B	Wnt Family Member 9B	Protein Coding	1
237	WNT16	Wnt Family Member 16	Protein Coding	1
238	WNT2	Wnt Family Member 2	Protein Coding	1
239	WNT2B	Wnt Family Member 2B	Protein Coding	1
240	WNT3	Wnt Family Member 3	Protein Coding	1
241	WNT3A	Wnt Family Member 3A	Protein Coding	1
242	WNT4	Wnt Family Member 4	Protein Coding	1
243	WNT5A	Wnt Family Member 5A	Protein Coding	1
244	WNT5B	Wnt Family Member 5B	Protein Coding	1
245	WNT6	Wnt Family Member 6	Protein Coding	1
246	WNT7A	Wnt Family Member 7A	Protein Coding	1
247	WNT7B	Wnt Family Member 7B	Protein Coding	1
248	WNT8A	Wnt Family Member 8A	Protein Coding	1
249	WNT8B	Wnt Family Member 8B	Protein Coding	1
250	ZNF354A	Zinc Finger Protein 354A	Protein Coding	1

Disorders associated with WNT Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Osteoporosis, juvenile	Enrichment	DKK1, WNT1, WNT3A	5.21
2	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1, MAP3K6	4.61
3	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, FZD2, WNT5A	4.61
4	Autosomal dominant robinow syndrome	Enrichment	DVL1, FZD2, WNT5A	4.61
5	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	4.22
6	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, FZD2, WNT5A	4.22
7	Autosomal recessive robinow syndrome	Enrichment	DVL1, FZD2, WNT5A	3.93
8	Polycystic liver disease	Enrichment	CTNNB1, HNF4A, LRP5, LRP6	3.65
9	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, HNF4A, LRP5, LRP6	3.65
10	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, CDH15, GNB1, PPP3CA, TCF4	3.53
11	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	3.49
12	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4, PSMB9	3.47
13	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF1A, HNF4A	3.47
14	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1, TP53	3.32
15	Primary hyperaldosteronism	Enrichment	CDH23, GNAS, TP53	3.32
16	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1, TP53	3.20
17	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.00
18	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4, PSMB8	3.00
19	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	HNF1B, WNT4	3.00
20	Desmoid tumor	Enrichment	APC, CTNNB1	3.00
21	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4, PSMB8	3.00
22	Chromophobe renal cell carcinoma	Enrichment	HNF1A, HNF1B	3.00
23	Intraocular pressure quantitative trait locus	Enrichment	CREBBP, ZEB1	3.00
24	Anastomosing haemangioma	Enrichment	GNA11, GNA14	3.00
25	Colorectal cancer	Enrichment	APC, CCND1, CDH1, CTNNA1, CTNNB1, FZD3, TP53	2.96
26	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	2.70
27	Maturity-onset diabetes of the young, type 3	Enrichment	HNF1A, HNF4A	2.70
28	Achromatopsia 4	Enrichment	GNAI3, GNAT2	2.70
29	Retinopathy of prematurity	Enrichment	FZD4, LRP5	2.70
30	Craniopharyngioma	Enrichment	APC, CTNNB1	2.70
31	Breast cancer	Enrichment	APC, CDH1, GNG3, HNF1A, JUN, TP53	2.59
32	Ovarian cancer	Enrichment	APC, CDH1, CTNNB1, HNF1A, HNF1B, MAP3K1, TP53	2.58
33	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, FZD2	2.49
34	Fuchs' endothelial dystrophy	Enrichment	TCF4, ZEB1	2.49
35	Melanoma, uveal	Enrichment	GNA11, PLCB4	2.32
36	Adrenocortical carcinoma	Enrichment	CTNNB1, TP53	2.32
37	Maturity-onset diabetes of the young	Enrichment	HNF1A, HNF1B, HNF4A	2.25
38	Craniosynostosis	Enrichment	CTNNA1, TCF12, TCF20	2.25
39	Hepatoblastoma	Enrichment	APC, CTNNB1, TP53	2.19
40	Gallbladder cancer	Enrichment	CTNNB1, TP53	2.18
41	Type 2 diabetes mellitus	Enrichment	HNF1A, HNF1B, HNF4A, TCF7L2	2.14
42	Tooth agenesis	Enrichment	LRP6, WNT10A, WNT10B	2.13
43	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS, TCF4	2.06
44	Isolated split hand-split foot malformation	Enrichment	BTRC, WNT10B	2.06
45	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	1.86
46	Prostate cancer	Enrichment	CDH1, HNF1B, TP53	1.80
47	Myelodysplastic syndrome	Enrichment	GNB1, TP53	1.78
48	Chiari malformation type i	Enrichment	DKK1	1.73
49	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	1.73
50	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	1.73
51	Hepatic adenomas, familial	Enrichment	HNF1A	1.73
52	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	1.73
53	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	1.73
54	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	1.73
55	Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Enrichment	CDH3	1.73
56	Elsahy-waters syndrome	Enrichment	CDH11	1.73
57	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	1.73
58	Exudative vitreoretinopathy 4	Enrichment	LRP5	1.73
59	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	1.73
60	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	1.73
61	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	1.73
62	Intellectual developmental disorder, autosomal dominant 3	Enrichment	CDH15	1.73
63	Mitral valve prolapse 2	Enrichment	DCHS1	1.73
64	Osseous heteroplasia, progressive	Enrichment	GNAS	1.73
65	Omodysplasia 2	Enrichment	FZD2	1.73
66	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	1.73
67	Prostate cancer, hereditary, 11	Enrichment	HNF1B	1.73
68	Split-hand/foot malformation 6	Enrichment	WNT10B	1.73
69	Tooth agenesis, selective, 7	Enrichment	LRP6	1.73
70	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	1.73
71	Caudal duplication anomaly	Enrichment	AXIN1	1.73
72	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	1.73
73	Tooth agenesis, selective, 8	Enrichment	WNT10B	1.73
74	Fetal encasement syndrome	Enrichment	CHUK	1.73
75	Ectodermal dysplasia 13, hair/tooth type	Enrichment	KREMEN1	1.73
76	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	1.73
77	46,xy sex reversal 6	Enrichment	MAP3K1	1.73
78	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	1.73
79	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	1.73
80	Ventricular tachycardia, familial	Enrichment	GNAI2	1.73
81	Wilms tumor 6	Enrichment	REST	1.73
82	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	1.73
83	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	1.73
84	Exudative vitreoretinopathy 8	Enrichment	LRP6	1.73
85	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.73
86	Teebi hypertelorism syndrome 2	Enrichment	CDH11	1.73
87	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	1.73
88	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	1.73
89	Pituitary adenoma 3, multiple types	Enrichment	GNAS	1.73
90	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	1.73
91	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	1.73
92	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.73
93	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	1.73
94	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.73
95	Bone marrow failure syndrome 5	Enrichment	TP53	1.73
96	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	1.73
97	Diarrhea 9	Enrichment	WNT2B	1.73
98	Papilloma of choroid plexus	Enrichment	TP53	1.73
99	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.73
100	Basal cell carcinoma 7	Enrichment	TP53	1.73
101	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	1.73
102	Anaplastic thyroid carcinoma	Enrichment	TP53	1.73
103	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	1.73
104	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	1.73
105	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	1.73
106	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	1.73
107	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	1.73
108	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	1.73
109	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	1.73
110	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.73
111	Hypotrichosis	Enrichment	CDH3	1.73
112	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	1.73
113	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.73
114	Santos syndrome	Enrichment	WNT7A	1.73
115	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	1.73
116	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	1.73
117	Deafness, autosomal dominant 27	Enrichment	REST	1.73
118	Dystonia 25	Enrichment	GNAL	1.73
119	Craniosynostosis 3	Enrichment	TCF12	1.73
120	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	1.73
121	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	1.73
122	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	1.73
123	Proteasome-associated autoinflammatory syndrome 6	Enrichment	PSMB9	1.73
124	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.73
125	Microphthalmia/coloboma 11	Enrichment	FZD5	1.73
126	Type 1 diabetes mellitus 20	Enrichment	HNF1A	1.73
127	Disorders of gnas inactivation	Enrichment	GNAS	1.73
128	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	1.73
129	Ductal carcinoma in situ	Enrichment	TP53	1.73
130	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	1.73
131	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	1.73
132	Fibromatosis, gingival, 5	Enrichment	REST	1.73
133	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	1.73
134	Ovarian small cell carcinoma	Enrichment	SMARCA4	1.73
135	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.73
136	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.73
137	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.73
138	Sick sinus syndrome 4	Enrichment	GNB2	1.73
139	Menke-hennekam syndrome 1	Enrichment	CREBBP	1.73
140	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.73
141	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	1.73
142	Neurodevelopmental disorder with neuromuscular and skeletal abnormalities	Enrichment	NRCAM	1.73
143	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.73
144	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.73
145	Developmental delay with variable intellectual impairment and behavioral abnormalities	Enrichment	TCF20	1.73
146	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	1.73
147	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	1.73
148	Tsh producing pituitary tumor	Enrichment	CDH23	1.73
149	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.73
150	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	1.73
151	Adenoid ameloblastoma	Enrichment	CTNNB1	1.73
152	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	1.73
153	Lrp5-related primary osteoporosis	Enrichment	LRP5	1.73
154	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.73
155	Immunodeficiency 112	Enrichment	MAP3K14	1.73
156	Breast lobular carcinoma	Enrichment	CDH1	1.73
157	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	1.73
158	Cerebral cavernous malformations 5	Enrichment	MAP3K3	1.73
159	Choroid plexus cancer	Enrichment	TP53	1.73
160	Familial adenomatous polyposis	Enrichment	APC	1.73
161	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.73
162	Menke-hennekam syndrome	Enrichment	CREBBP	1.73
163	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.73
164	Hypogonadotropic hypogonadism 26 with or without anosmia	Enrichment	TCF12	1.73
165	Monostotic fibrous dysplasia	Enrichment	GNAS	1.73
166	Gardner syndrome	Enrichment	APC	1.73
167	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	1.73
168	Medullary sponge kidney	Enrichment	HNF1B	1.73
169	Gnao1-related disorder	Enrichment	GNAO1	1.73
170	5q22 microdeletion syndrome	Enrichment	APC	1.73
171	Attenuated familial adenomatous polyposis	Enrichment	APC	1.73
172	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.73
173	Renal dysplasia, bilateral	Enrichment	HNF1B	1.73
174	Premature aging	Enrichment	VIM	1.73
175	Phakomatosis cesiomarmorata	Enrichment	GNA11	1.73
176	Unilateral multicystic dysplastic kidney	Enrichment	HNF1B	1.73
177	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	1.73
178	Verrucous hemangioma	Enrichment	MAP3K3	1.73
179	Kaposiform hemangioendothelioma	Enrichment	GNA14	1.73
180	Renal dysplasia, unilateral	Enrichment	HNF1B	1.73
181	Mazabraud syndrome	Enrichment	GNAS	1.73
182	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	1.73
183	Nik deficiency	Enrichment	MAP3K14	1.73
184	Microcystic stromal tumor	Enrichment	CTNNB1	1.73
185	Myeloma, multiple	Enrichment	CCND1, CREBBP, TCF3, TP53	1.71
186	Dystonia	Enrichment	CAMK2B, GNAL, GNB1	1.58
187	Microcephaly	Enrichment	CAMK2B, CTNNB1, GNAO1, GNB1, PSMC3, TCF4	1.58
188	Osteoporosis	Enrichment	LRP5, WNT1	1.58
189	Medulloblastoma	Enrichment	APC, CTNNB1	1.58
190	Renal cell carcinoma, nonpapillary	Enrichment	HNF1A, HNF1B	1.52
191	Corpus callosum, agenesis of	Enrichment	CDH2, CREBBP	1.52
192	Isolated corpus callosum agenesis	Enrichment	CDH2, CREBBP	1.52
193	Rare genetic intellectual disability	Enrichment	CREBBP, GNAO1	1.52
194	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2, CREBBP	1.52
195	Tubulointerstitial kidney disease, autosomal dominant 1	Enrichment	HNF1B	1.44
196	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.44
197	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.44
198	Burkitt lymphoma	Enrichment	MYC	1.44
199	Renal cysts and diabetes syndrome	Enrichment	HNF1B	1.44
200	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	1.44
201	Congenital anomalies of kidney and urinary tract 2	Enrichment	HNF1B	1.44
202	Mitral valve prolapse 1	Enrichment	DCHS1	1.44
203	Maturity-onset diabetes of the young, type 1	Enrichment	HNF4A	1.44
204	Fibromatosis, gingival, 1	Enrichment	REST	1.44
205	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.44
206	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.44
207	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.44
208	Van buchem disease	Enrichment	LRP5	1.44
209	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.44
210	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.44
211	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.44
212	Thumb deformity	Enrichment	CREBBP	1.44
213	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.44
214	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.44
215	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.44
216	Van maldergem syndrome 1	Enrichment	DCHS1	1.44
217	Hypotrichosis, congenital, with juvenile macular dystrophy	Enrichment	CDH3	1.44
218	Cervical cancer	Enrichment	TP53	1.44
219	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.44
220	Tetraamelia syndrome 1	Enrichment	WNT3	1.44
221	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.44
222	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	1.44
223	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1	1.44
224	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.44
225	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.44
226	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.44
227	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.44
228	Angioma, tufted	Enrichment	GNA14	1.44
229	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.44
230	Deafness, autosomal recessive 84a	Enrichment	CDH23	1.44
231	Spermatogenic failure 17	Enrichment	PLCZ1	1.44
232	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.44
233	Lymphoma, hodgkin, classic	Enrichment	TP53	1.44
234	Proteasome-associated autoinflammatory syndrome 5	Enrichment	PSMB10	1.44
235	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.44
236	Immunodeficiency 121 with autoinflammation	Enrichment	PSMB10	1.44
237	Birk-aharoni syndrome	Enrichment	PSMC1	1.44
238	Hyperuricemic nephropathy, familial juvenile, 3	Enrichment	HNF1B	1.44
239	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.44
240	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	1.44
241	Combined saposin deficiency	Enrichment	CDH23	1.44
242	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.44
243	Split hand-foot malformation	Enrichment	LEF1	1.44
244	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.44
245	Cataract 30	Enrichment	VIM	1.44
246	Pseudohypoparathyroidism	Enrichment	GNAS	1.44
247	Congenital fibrosarcoma	Enrichment	TP53	1.44
248	Li-fraumeni syndrome 1	Enrichment	TP53	1.44
249	Sarcoma	Enrichment	TP53	1.44
250	Ocular melanoma	Enrichment	PLCB4	1.44
251	Otosclerosis 12	Enrichment	SMARCA4	1.44
252	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.44
253	Periampullary adenoma	Enrichment	APC	1.44
254	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.44
255	Cervix carcinoma	Enrichment	TP53	1.44
256	Hodgkin's lymphoma	Enrichment	TP53	1.44
257	Hypopituitarism	Enrichment	GNAI2	1.44
258	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.44
259	Combined psap deficiency	Enrichment	CDH23	1.44
260	Mitochondrial dna depletion syndrome 15	Enrichment	TFAM	1.44
261	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.44
262	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	1.44
263	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.44
264	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.44
265	Hyperinsulinism	Enrichment	HNF4A	1.44
266	Teratoma	Enrichment	CTNNB1	1.44
267	Osteosclerosis	Enrichment	LRP5	1.44
268	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.44
269	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	1.44
270	Familial isolated pituitary adenoma	Enrichment	CDH23	1.44
271	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.44
272	Cerebral visual impairment	Enrichment	GNB1	1.44
273	Submucosal cleft palate	Enrichment	UBB	1.44
274	Phakomatosis cesioflammea	Enrichment	GNA11	1.44
275	Cleft hard palate	Enrichment	UBB	1.44
276	Cleft palate, isolated	Enrichment	GNB1, SMARCA4	1.42
277	Autism	Enrichment	CAMK2G, CREBBP, TCF20, TCF7L2	1.36
278	Gastric cancer	Enrichment	APC, CDH1, TP53	1.35
279	Congenital nervous system abnormality	Enrichment	CAMK2B, CREBBP, CTNNB1, GNAO1, GNB5	1.33
280	Nervous system disease	Enrichment	CAMK2B, CREBBP, CTNNB1, GNAO1, GNB5	1.33
281	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TP53	1.33
282	West syndrome	Enrichment	CSNK1E, GNAO1, PLCB1	1.33
283	Hereditary breast carcinoma	Enrichment	APC, CDH1, TP53	1.33
284	Mccune-albright syndrome	Enrichment	GNAS	1.27
285	Uvula, bifid	Enrichment	UBB	1.27
286	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.27
287	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.27
288	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	1.27
289	Osteogenic sarcoma	Enrichment	TP53	1.27
290	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	1.27
291	Cleft soft palate	Enrichment	UBB	1.27
292	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	1.27
293	Nasopharyngeal carcinoma	Enrichment	TP53	1.27
294	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.27
295	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.27
296	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.27
297	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.27
298	Chromosome 17q12 deletion syndrome	Enrichment	HNF1B	1.27
299	Anus, imperforate	Enrichment	CTNNB1	1.27
300	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.27
301	Nephrotic syndrome, type 24	Enrichment	DAAM2	1.27
302	Keratoderma-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	HNF1A	1.27
303	Tethered spinal cord syndrome	Enrichment	CREBBP	1.27
304	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.27
305	Nail disease	Enrichment	FZD6	1.27
306	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.27
307	Anaplastic astrocytoma	Enrichment	TP53	1.27
308	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.27
309	Squamous cell carcinoma	Enrichment	TP53	1.27
310	Adenocarcinoma	Enrichment	TP53	1.27
311	Bone osteosarcoma	Enrichment	TP53	1.27
312	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.27
313	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.27
314	Tetraamelia syndrome	Enrichment	WNT3	1.27
315	Colon adenocarcinoma	Enrichment	APC	1.27
316	Advanced sleep phase syndrome	Enrichment	CSNK1D	1.27
317	Melanoma of soft tissue	Enrichment	CREB1	1.27
318	Thyroid hemiagenesis	Enrichment	PSMD3	1.27
319	Apc-associated polyposis conditions	Enrichment	APC	1.27
320	Attention deficit-hyperactivity disorder	Enrichment	GNB5, TCF20	1.21
321	Brittle bone disorder	Enrichment	LRP5, WNT1	1.18
322	Congenital stationary night blindness	Enrichment	GNAT1, GNB3	1.18
323	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.14
324	Small cell cancer of the lung	Enrichment	TP53	1.14
325	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.14
326	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.14
327	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.14
328	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.14
329	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.14
330	Pitt-hopkins syndrome	Enrichment	TCF4	1.14
331	Pilomatrixoma	Enrichment	CTNNB1	1.14
332	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.14
333	Pituitary adenoma 5, multiple types	Enrichment	CDH23	1.14
334	Alazami syndrome	Enrichment	CTNNB1	1.14
335	Mantle cell lymphoma	Enrichment	CCND1	1.14
336	Lung sarcomatoid carcinoma	Enrichment	TP53	1.14
337	Orofacial cleft	Enrichment	LRP6	1.14
338	Hereditary ataxia	Enrichment	PRKCG	1.14
339	Ectodermal dysplasia	Enrichment	WNT10A	1.14
340	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.14
341	Prolactinoma	Enrichment	CDH23	1.14
342	Corneal dystrophy	Enrichment	ZEB1	1.14
343	Eyelid coloboma	Enrichment	FZD5	1.14
344	Vacterl association	Enrichment	CDH13	1.14
345	Non-syndromic bicoronal craniosynostosis	Enrichment	TCF12	1.14
346	Vitreoretinopathy	Enrichment	LRP5	1.14
347	Orofacial clefting syndrome	Enrichment	LRP6	1.14
348	Clear cell papillary renal cell carcinoma	Enrichment	HNF1A	1.14
349	Gingival fibromatosis	Enrichment	REST	1.14
350	Lens coloboma	Enrichment	FZD5	1.14
351	Familial sick sinus syndrome	Enrichment	GNB2	1.14
352	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E, GNAO1	1.11
353	Capillary malformations, congenital	Enrichment	GNA11	1.05
354	Vater/vacterl association	Enrichment	CDH13	1.05
355	Von hippel-lindau syndrome	Enrichment	CCND1	1.05
356	Norrie disease	Enrichment	FZD4	1.05
357	Rhabdomyosarcoma 2	Enrichment	TP53	1.05
358	Chondrosarcoma, extraskeletal myxoid	Enrichment	TCF12	1.05
359	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.05
360	Familial adenomatous polyposis 1	Enrichment	APC	1.05
361	Cholangitis, primary sclerosing	Enrichment	TCF4	1.05
362	Lymphoma	Enrichment	TP53	1.05
363	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.05
364	Histiocytoid hemangioma	Enrichment	VIM	1.05
365	Acute megakaryocytic leukemia	Enrichment	TP53	1.05
366	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.05
367	Coloboma of choroid and retina	Enrichment	FZD5	1.05
368	Inherited cancer-predisposing syndrome	Enrichment	APC, CDH1, CTNNA1, SMARCA4, TP53	1.01
369	Bladder cancer	Enrichment	CTNNB1, TP53	1.00
370	Developmental dysplasia of the hip 1	Enrichment	PSMC3	0.98
371	Li-fraumeni syndrome	Enrichment	TP53	0.98
372	Coloboma of optic nerve	Enrichment	FZD5	0.98
373	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	0.98
374	Weyers acrofacial dysostosis	Enrichment	CTNNB1	0.98
375	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	0.98
376	Split-hand/foot malformation 1	Enrichment	LEF1	0.98
377	Hemihyperplasia, isolated	Enrichment	RHOA	0.98
378	Type 1 diabetes mellitus	Enrichment	HNF1A	0.98
379	Usher syndrome, type id	Enrichment	CDH23	0.98
380	Deafness, autosomal recessive 12	Enrichment	CDH23	0.98
381	Renal dysplasia, cystic	Enrichment	WNT9B	0.98
382	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	0.98
383	Renal hypoplasia	Enrichment	WNT9B	0.98
384	Diarrhea	Enrichment	WNT2B	0.98
385	Patent ductus arteriosus	Enrichment	PSMC3	0.98
386	Clear cell renal cell carcinoma	Enrichment	HNF1A	0.98
387	Breast adenocarcinoma	Enrichment	TP53	0.98
388	Hypertrichosis	Enrichment	CREBBP	0.98
389	Multicystic kidney dysplasia	Enrichment	FZD3	0.98
390	Syndromic rod-cone dystrophy	Enrichment	CDH23	0.98
391	Cleft lip with or without cleft palate	Enrichment	CDH1	0.98
392	Multicystic dysplastic kidney	Enrichment	FZD3	0.98
393	Esophageal cancer	Enrichment	TP53	0.91
394	Meniere disease	Enrichment	CDH23	0.91
395	Squamous cell carcinoma, head and neck	Enrichment	TP53	0.91
396	Coats disease	Enrichment	FZD4	0.91
397	Usher syndrome, type iia	Enrichment	CDH23	0.91
398	Brachydactyly	Enrichment	GNAS	0.91
399	Essential thrombocythemia	Enrichment	TP53	0.91
400	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	0.91
401	Genetic steroid-resistant nephrotic syndrome	Enrichment	DAAM2, PLCE1	0.89
402	Glioma susceptibility 1	Enrichment	TP53	0.86
403	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	0.86
404	Lymphoma, non-hodgkin, familial	Enrichment	TP53	0.86
405	Lennox-gastaut syndrome	Enrichment	MAPK10	0.86
406	Hypothyroidism	Enrichment	GNB1	0.86
407	Neuroblastoma	Enrichment	SMARCA4	0.86
408	Choreatic disease	Enrichment	GNAO1	0.86
409	Autism spectrum disorder	Enrichment	GNB1, TCF12, TCF20, TCF4	0.85
410	Nephrotic syndrome, type 1	Enrichment	PLCE1	0.81
411	Inflammatory bowel disease 1	Enrichment	PRKCQ	0.81
412	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	0.81
413	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.81
414	Ventricular septal defect	Enrichment	SMARCA4	0.81
415	Colonic benign neoplasm	Enrichment	APC	0.81
416	Hypotrichosis simplex	Enrichment	CDH3	0.81
417	Renal agenesis, bilateral	Enrichment	WNT9B	0.81
418	Cerebral palsy	Enrichment	GNB1, SMARCA4	0.79
419	Cat eye syndrome	Enrichment	FZD5	0.77
420	Cataract 30, multiple types	Enrichment	VIM	0.77
421	Omenn syndrome	Enrichment	PSMB10	0.77
422	Stroke, ischemic	Enrichment	PRKCH	0.77
423	Polymicrogyria	Enrichment	PSMC3	0.77
424	Achromatopsia	Enrichment	GNAT2	0.77
425	Familial colorectal cancer	Enrichment	TP53	0.77
426	Autosomal non-syndromic agammaglobulinemia	Enrichment	TCF3	0.77
427	Pectus excavatum	Enrichment	TCF20	0.73
428	Leukemia, acute lymphoblastic	Enrichment	GNB1	0.73
429	Usher syndrome type 2	Enrichment	CDH23	0.73
430	Atrial heart septal defect	Enrichment	SMARCA4	0.73
431	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	0.73
432	Movement disease	Enrichment	GNAO1	0.73
433	Diabetes mellitus	Enrichment	HNF1A	0.73
434	Interatrial communication	Enrichment	SMARCA4	0.73
435	Complex neurodevelopmental disorder	Enrichment	GNB2, NRCAM, TCF20, TCF7L2	0.71
436	Epicanthus	Enrichment	TCF4	0.70
437	Digeorge syndrome	Enrichment	HNF1A	0.70
438	Lip and oral cavity carcinoma	Enrichment	TP53	0.70
439	Microphthalmia/coloboma 12	Enrichment	FZD5	0.67
440	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	0.67
441	Osteogenesis imperfecta, type iv	Enrichment	WNT1	0.67
442	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.67
443	Stereotypic movement disorder	Enrichment	TCF4	0.67
444	Chronic kidney disease	Enrichment	WNT9B	0.67
445	Cone-rod dystrophy 6	Enrichment	GNAT2	0.64
446	Lung cancer susceptibility 3	Enrichment	TP53	0.64
447	Heart disease	Enrichment	CREBBP	0.64
448	Cleft lip/palate	Enrichment	CDH1	0.64
449	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	0.64
450	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	0.64
451	Coloboma of macula	Enrichment	FZD5	0.61
452	Coffin-siris syndrome 1	Enrichment	SMARCA4	0.61
453	Wilms tumor 1	Enrichment	REST	0.61
454	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.61
455	Usher syndrome, type i	Enrichment	CDH23	0.61
456	Hydrocephalus	Enrichment	FZD3	0.61
457	Familial hypercholesterolemia	Enrichment	SMARCA4	0.61
458	Rhabdomyosarcoma	Enrichment	TP53	0.59
459	Gliosarcoma	Enrichment	TP53	0.59
460	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, TP53	0.57
461	Hypertension, essential	Enrichment	GNB3	0.57
462	Giant cell glioblastoma	Enrichment	TP53	0.57
463	Patent foramen ovale	Enrichment	PSMC3	0.55
464	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	0.55
465	Hereditary retinal dystrophy	Enrichment	CDH23, CDH3, CTNNA1, FZD4, GNAT1, GNAT2, LRP5	0.54
466	Fundus dystrophy	Enrichment	CDH23, CDH3, CTNNA1, FZD4, GNAT1, GNAT2, LRP5	0.54
467	Arteriovenous malformations of the brain	Enrichment	CDH2	0.53
468	Macs syndrome	Enrichment	WNT7B	0.51
469	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.51
470	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.49
471	Endometrial cancer	Enrichment	CDH1	0.49
472	Myocardial infarction	Enrichment	PSMA6	0.47
473	Microphthalmia	Enrichment	WNT7B	0.47
474	Diamond-blackfan anemia 1	Enrichment	TP53	0.46
475	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.46
476	Ear malformation	Enrichment	CDH23	0.44
477	Cone dystrophy	Enrichment	GNAT2	0.44
478	Autoinflammatory disease	Enrichment	PSMB8	0.44
479	Scoliosis	Enrichment	CREBBP	0.44
480	Pancreatic cancer	Enrichment	TP53	0.43
481	Hydrops fetalis, nonimmune	Enrichment	FZD6	0.42
482	Auditory neuropathy	Enrichment	CDH2	0.42
483	Strabismus	Enrichment	GNB1	0.40
484	Isolated joubert syndrome	Enrichment	CBY1	0.37
485	Non-immune hydrops fetalis	Enrichment	FZD6	0.36
486	Lung cancer	Enrichment	MAP3K8	0.35
487	Usher syndrome	Enrichment	CDH23	0.34
488	Cakut	Enrichment	HNF1B	0.33
489	Eye disease	Enrichment	GNAT2	0.32
490	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.31
491	Diamond-blackfan anemia	Enrichment	TP53	0.31
492	Non-syndromic genetic deafness	Enrichment	CDH23	0.31
493	Leukemia, acute myeloid	Enrichment	TP53	0.28
494	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.27
495	Distal arthrogryposis	Enrichment	FZD3	0.27
496	Nonsyndromic hearing loss	Enrichment	CDH23	0.27
497	Centralopathic epilepsy	Enrichment	PLCB1	0.26
498	Nephrotic syndrome	Enrichment	PLCE1	0.26
499	Sensorineural hearing loss	Enrichment	CDH23	0.23
500	Joubert syndrome 1	Enrichment	CBY1	0.22
501	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.22
502	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.21
503	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.19
504	Deafness, autosomal recessive	Enrichment	CDH23	0.16
505	Autosomal recessive nonsyndromic deafness	Enrichment	CDH23	0.16
506	Retinitis pigmentosa	Enrichment	CDH23, CDH3, GNAT1	0.12
507	Rare genetic deafness	Enrichment	CDH23	0.11
508	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CDH23	0.09

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

WNT Signaling

Pathway Network for WNT Signaling

Member Pathways for WNT Signaling

Pathways in the WNT Signaling SuperPath

Associated Genes for WNT Signaling

Associated Disorders for WNT Signaling

Disorders associated with WNT Signaling SuperPath

STRING Interaction Network for WNT Signaling

Sources for WNT Signaling