Wnt/beta-catenin signaling pathway in leukemia

No Pathway Network information available for Wnt/beta-catenin signaling pathway in leukemia

Pathways in the Wnt/beta-catenin signaling pathway in leukemia SuperPath

#	Name	Source	Genes
1	Wnt/beta-catenin signaling pathway in leukemia	WikiPathways	AKT1 APC AXIN2 BCL9 CCND1 CSNK1A1 DKK1 FLT3 GSK3B JUP LEF1 LRP5 LRP6 MYC PML PPARD PYGO1 RARA RUNX1T1 SALL4 TCF3 WIF1 WNT1 ZBTB16 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CCND1	Cyclin D1	Protein Coding	1
2	JUP	Junction Plakoglobin	Protein Coding	1
3	RUNX1T1	RUNX1 Partner Transcriptional Co-Repressor 1	Protein Coding	1
4	AXIN2	Axin 2	Protein Coding	1
5	ZBTB16	Zinc Finger And BTB Domain Containing 16	Protein Coding	1
6	WNT1	Wnt Family Member 1	Protein Coding	1
7	TCF3	Transcription Factor 3	Protein Coding	1
8	BCL9	BCL9 Transcription Coactivator	Protein Coding	1
9	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
10	SALL4	Spalt Like Transcription Factor 4	Protein Coding	1
11	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
12	PML	PML Nuclear Body Scaffold	Protein Coding	1
13	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
14	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
15	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
16	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
17	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
18	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
19	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
20	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
21	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
22	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
23	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
24	PYGO1	Pygopus Family PHD Finger 1	Protein Coding	1

Disorders associated with Wnt/beta-catenin signaling pathway in leukemia SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Acute promyelocytic leukemia	Enrichment	PML, RARA, ZBTB16	5.86
2	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3, MYC, ZBTB16	5.07
3	Osteoporosis, juvenile	Enrichment	DKK1, WNT1	5.05
4	Colorectal cancer	Enrichment	AKT1, APC, AXIN2, CCND1	4.82
5	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, RUNX1T1	4.52
6	Myeloma, multiple	Enrichment	CCND1, FLT3, TCF3	3.90
7	Osteoporosis	Enrichment	LRP5, WNT1	3.57
8	Polycystic liver disease	Enrichment	LRP5, LRP6	3.40
9	Autosomal dominant polycystic liver disease	Enrichment	LRP5, LRP6	3.40
10	Tooth agenesis	Enrichment	AXIN2, LRP6	3.17
11	Ovarian cancer	Enrichment	AKT1, APC, AXIN2	3.14
12	Brittle bone disorder	Enrichment	LRP5, WNT1	3.13
13	Chiari malformation type i	Enrichment	DKK1	2.75
14	Proteus syndrome	Enrichment	AKT1	2.75
15	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.75
16	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.75
17	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.75
18	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	2.75
19	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.75
20	Skeletal defects, genital hypoplasia, and impaired intellectual development	Enrichment	ZBTB16	2.75
21	Ivic syndrome	Enrichment	SALL4	2.75
22	Tooth agenesis, selective, 7	Enrichment	LRP6	2.75
23	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.75
24	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.75
25	Naxos disease	Enrichment	JUP	2.75
26	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	2.75
27	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.75
28	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.75
29	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.75
30	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	2.75
31	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.75
32	Cowden syndrome 6	Enrichment	AKT1	2.75
33	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.75
34	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.75
35	Familial adenomatous polyposis	Enrichment	APC	2.75
36	Gardner syndrome	Enrichment	APC	2.75
37	Sall4-related disorders	Enrichment	SALL4	2.75
38	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.75
39	5q22 microdeletion syndrome	Enrichment	APC	2.75
40	Attenuated familial adenomatous polyposis	Enrichment	APC	2.75
41	Hereditary breast carcinoma	Enrichment	AKT1, APC	2.57
42	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.45
43	Burkitt lymphoma	Enrichment	MYC	2.45
44	Van buchem disease	Enrichment	LRP5	2.45
45	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.45
46	Duane-radial ray syndrome	Enrichment	SALL4	2.45
47	Split hand-foot malformation	Enrichment	LEF1	2.45
48	Periampullary adenoma	Enrichment	APC	2.45
49	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.45
50	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.45
51	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	2.45
52	Osteosclerosis	Enrichment	LRP5	2.45
53	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.45
54	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	2.45
55	Desmoid disease, hereditary	Enrichment	APC	2.28
56	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	2.28
57	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	2.28
58	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.28
59	Desmoid tumor	Enrichment	APC	2.28
60	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.28
61	Duane retraction syndrome	Enrichment	SALL4	2.28
62	Colon adenocarcinoma	Enrichment	APC	2.28
63	Mixed phenotype acute leukemia with t	Enrichment	FLT3	2.28
64	Apc-associated polyposis conditions	Enrichment	APC	2.28
65	Mantle cell lymphoma	Enrichment	CCND1	2.15
66	Orofacial cleft	Enrichment	LRP6	2.15
67	Chronic myelomonocytic leukemia	Enrichment	FLT3	2.15
68	Retinopathy of prematurity	Enrichment	LRP5	2.15
69	Craniopharyngioma	Enrichment	APC	2.15
70	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3	2.15
71	Vitreoretinopathy	Enrichment	LRP5	2.15
72	Orofacial clefting syndrome	Enrichment	LRP6	2.15
73	Breast cancer	Enrichment	AKT1, APC	2.11
74	Exudative vitreoretinopathy 1	Enrichment	LRP5	2.05
75	Von hippel-lindau syndrome	Enrichment	CCND1	2.05
76	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	SALL4	2.05
77	Familial adenomatous polyposis 1	Enrichment	APC	2.05
78	Acute myeloid leukemia with maturation	Enrichment	FLT3	2.05
79	Split-hand/foot malformation 1	Enrichment	LEF1	1.98
80	Breast adenocarcinoma	Enrichment	AKT1	1.98
81	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.91
82	Exudative vitreoretinopathy	Enrichment	LRP5	1.85
83	Tooth agenesis, selective, 1	Enrichment	AXIN2	1.80
84	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.80
85	Colonic benign neoplasm	Enrichment	APC	1.80
86	Cowden syndrome	Enrichment	AKT1	1.80
87	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.76
88	Autosomal non-syndromic agammaglobulinemia	Enrichment	TCF3	1.76
89	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.71
90	Meningioma	Enrichment	AKT1	1.68
91	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.68
92	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.68
93	Inherited cancer-predisposing syndrome	Enrichment	APC, AXIN2	1.65
94	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.64
95	Nk-cell enteropathy	Enrichment	RUNX1T1	1.64
96	Medulloblastoma	Enrichment	APC	1.61
97	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.61
98	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.58
99	Wolff-parkinson-white syndrome	Enrichment	JUP	1.55
100	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.55
101	Hepatoblastoma	Enrichment	APC	1.44
102	Hepatocellular carcinoma	Enrichment	APC	1.42
103	Hirschsprung disease 1	Enrichment	AXIN2	1.30
104	Leukemia, acute myeloid	Enrichment	FLT3	1.16
105	Gastric cancer	Enrichment	APC	1.13
106	Dilated cardiomyopathy	Enrichment	JUP	0.88
107	Hereditary retinal dystrophy	Enrichment	LRP5	0.39
108	Fundus dystrophy	Enrichment	LRP5	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Wnt/beta-catenin signaling pathway in leukemia

Pathway Network for Wnt/beta-catenin signaling pathway in leukemia

Member Pathways for Wnt/beta-catenin signaling pathway in leukemia

Pathways in the Wnt/beta-catenin signaling pathway in leukemia SuperPath

Associated Genes for Wnt/beta-catenin signaling pathway in leukemia

Associated Disorders for Wnt/beta-catenin signaling pathway in leukemia

Disorders associated with Wnt/beta-catenin signaling pathway in leukemia SuperPath

STRING Interaction Network for Wnt/beta-catenin signaling pathway in leukemia

Sources for Wnt/beta-catenin signaling pathway in leukemia