wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

No Pathway Network information available for wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

#	Name	Source	Genes
1	wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)	GeneGo (Thomson Reuters)	CFTR PIK3C3 PIK3R4 RAB27A RAB7A RAB9A RILP STX8 SYTL5 UNC13D VAMP8 VTI1B (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
2	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
3	RAB27A	RAB27A, Member RAS Oncogene Family	Protein Coding	1
4	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
5	VAMP8	Vesicle Associated Membrane Protein 8	Protein Coding	1
6	RAB9A	RAB9A, Member RAS Oncogene Family	Protein Coding	1
7	STX8	Syntaxin 8	Protein Coding	1
8	VTI1B	Vesicle Transport Through Interaction With T-SNAREs 1B	Protein Coding	1
9	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
10	RILP	Rab Interacting Lysosomal Protein	Protein Coding	1
11	SYTL5	Synaptotagmin Like 5	Protein Coding	1
12	UNC13D	Unc-13 Homolog D	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoinflammatory disease	Enrichment	RAB27A, UNC13D	3.71
2	Griscelli syndrome, type 2	Enrichment	RAB27A	3.05
3	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	3.05
4	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	3.05
5	Griscelli syndrome	Enrichment	RAB27A	3.05
6	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	3.05
7	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.75
8	Hemophagocytic lymphohistiocytosis, familial, 3	Enrichment	UNC13D	2.75
9	Nuchal bleb, familial	Enrichment	CFTR	2.58
10	Idiopathic bronchiectasis	Enrichment	CFTR	2.45
11	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	UNC13D	2.35
12	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	2.10
13	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	2.10
14	Hereditary chronic pancreatitis	Enrichment	CFTR	1.91
15	Lynch syndrome	Enrichment	CFTR	1.88
16	Pancreatitis, hereditary	Enrichment	CFTR	1.83
17	Multisystem inflammatory syndrome in children	Enrichment	RAB27A	1.71
18	Cystic fibrosis	Enrichment	CFTR	1.55
19	Male infertility	Enrichment	CFTR	1.53
20	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	1.31
21	Hereditary retinal dystrophy	Enrichment	RILP	0.64
22	Fundus dystrophy	Enrichment	RILP	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)