YAP1- and WWTR1 (TAZ)-stimulated gene expression

No Pathway Network information available for YAP1- and WWTR1 (TAZ)-stimulated gene expression

Pathways in the YAP1- and WWTR1 (TAZ)-stimulated gene expression SuperPath

#	Name	Source	Genes
1	YAP1- and WWTR1 (TAZ)-stimulated gene expression	Reactome	CCN2 GATA4 HIPK1 HIPK2 KAT2B NKX2-5 NPPA RUNX2 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 WWTR1 YAP1 (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
2	NKX2-5	NK2 Homeobox 5	Protein Coding	1
3	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
4	HIPK1	Homeodomain Interacting Protein Kinase 1	Protein Coding	1
5	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
6	GATA4	GATA Binding Protein 4	Protein Coding	1
7	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	1
8	NPPA	Natriuretic Peptide A	Protein Coding	1
9	TBX5	T-Box Transcription Factor 5	Protein Coding	1
10	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	1
11	TEAD4	TEA Domain Transcription Factor 4	Protein Coding	1
12	TEAD3	TEA Domain Transcription Factor 3	Protein Coding	1
13	TEAD2	TEA Domain Transcription Factor 2	Protein Coding	1
14	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
15	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1

Disorders associated with YAP1- and WWTR1 (TAZ)-stimulated gene expression SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Heart disease	Enrichment	GATA4, NKX2-5, TBX5	6.40
2	Patent foramen ovale	Enrichment	GATA4, NKX2-5, TBX5	6.05
3	Familial atrial fibrillation	Enrichment	GATA4, NKX2-5, NPPA	5.66
4	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	5.16
5	Atrial heart septal defect	Enrichment	NKX2-5, TBX5	4.20
6	Interatrial communication	Enrichment	NKX2-5, TBX5	4.20
7	Heart, malformation of	Enrichment	GATA4, TBX5	3.76
8	Tetralogy of fallot	Enrichment	GATA4, NKX2-5	3.44
9	Atrial septal defect 7 with or without atrioventricular conduction defects	Enrichment	NKX2-5	2.96
10	Hypothyroidism, congenital, nongoitrous, 5	Enrichment	NKX2-5	2.96
11	Holt-oram syndrome	Enrichment	TBX5	2.96
12	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.96
13	Atrioventricular septal defect 4	Enrichment	GATA4	2.96
14	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.96
15	Atrial septal defect 2	Enrichment	GATA4	2.96
16	Ventricular septal defect 3	Enrichment	NKX2-5	2.96
17	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.96
18	Hypoplastic left heart syndrome 2	Enrichment	NKX2-5	2.96
19	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.96
20	Aortic arch interruption	Enrichment	NKX2-5	2.96
21	Atrial heart septal defect 7	Enrichment	NKX2-5	2.96
22	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.96
23	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	2.66
24	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.66
25	Thumb deformity	Enrichment	TBX5	2.66
26	Kyphomelic dysplasia	Enrichment	CCN2	2.66
27	Atrial fibrillation, familial, 6	Enrichment	NPPA	2.66
28	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.66
29	Retinitis pigmentosa 14	Enrichment	TEAD3	2.66
30	46,xy sex reversal 3	Enrichment	GATA4	2.66
31	Aortic valve disease 2	Enrichment	TBX5	2.66
32	Familial isolated congenital asplenia	Enrichment	NKX2-5	2.66
33	Deletion 5q35	Enrichment	NKX2-5	2.66
34	Isolated atrial standstill	Enrichment	NPPA	2.66
35	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.48
36	Atrial standstill 2	Enrichment	NPPA	2.48
37	Cleidocranial dysplasia	Enrichment	RUNX2	2.48
38	Dilated cardiomyopathy	Enrichment	NKX2-5, TBX5	2.46
39	Hereditary progressive cardiac conduction defect	Enrichment	NKX2-5	2.35
40	Mitral valve insufficiency	Enrichment	TBX5	2.35
41	Transposition of the great arteries	Enrichment	GATA4	2.35
42	Pseudomyogenic hemangioendothelioma	Enrichment	WWTR1	2.35
43	Atrioventricular septal defect	Enrichment	TBX5	2.26
44	Ventricular septal defect 1	Enrichment	GATA4	2.26
45	Congenital heart defects, multiple types, 4	Enrichment	GATA4	2.26
46	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	2.26
47	Persistent truncus arteriosus	Enrichment	NKX2-5	2.26
48	Atrial septal defect 1	Enrichment	TBX5	2.18
49	Conotruncal heart malformations	Enrichment	NKX2-5	2.18
50	Double outlet right ventricle	Enrichment	NKX2-5	2.18
51	Limited scleroderma	Enrichment	CCN2	2.18
52	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	NKX2-5	2.11
53	Hypoplastic left heart syndrome	Enrichment	NKX2-5	2.05
54	Ventricular septal defect	Enrichment	TBX5	2.00
55	Aortic valve disease 1	Enrichment	NKX2-5	1.85
56	Microphthalmia/coloboma 12	Enrichment	YAP1	1.85
57	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.81
58	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.81
59	Coloboma of macula	Enrichment	YAP1	1.78
60	Long qt syndrome 1	Enrichment	TBX5	1.49
61	Left ventricular noncompaction	Enrichment	NKX2-5	1.42
62	Nephrotic syndrome	Enrichment	RUNX2	1.33
63	Myeloma, multiple	Enrichment	YAP1	1.22
64	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	1.22
65	Leber plus disease	Enrichment	TEAD3	1.00
66	Hereditary retinal dystrophy	Enrichment	TEAD3	0.56
67	Fundus dystrophy	Enrichment	TEAD3	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

YAP1- and WWTR1 (TAZ)-stimulated gene expression

Pathway Network for YAP1- and WWTR1 (TAZ)-stimulated gene expression

Member Pathways for YAP1- and WWTR1 (TAZ)-stimulated gene expression

Pathways in the YAP1- and WWTR1 (TAZ)-stimulated gene expression SuperPath

Associated Genes for YAP1- and WWTR1 (TAZ)-stimulated gene expression

Associated Disorders for YAP1- and WWTR1 (TAZ)-stimulated gene expression

Disorders associated with YAP1- and WWTR1 (TAZ)-stimulated gene expression SuperPath

STRING Interaction Network for YAP1- and WWTR1 (TAZ)-stimulated gene expression

Sources for YAP1- and WWTR1 (TAZ)-stimulated gene expression