Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

#	Name	Source	Genes
1	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCC4 ABCC5 ABCG2 CYP2A6 CYP2C9 CYP2E1 CYP3A4 DTYMK NME1 NME2 POR SLC22A11 SLC22A6 SLC22A7 SLC22A8 SLC28A1 SLC28A3 TK1 UGT2B7 (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC28A3	Solute Carrier Family 28 Member 3	Protein Coding	1
2	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
3	TK1	Thymidine Kinase 1	Protein Coding	1
4	DTYMK	Deoxythymidylate Kinase	Protein Coding	1
5	POR	Cytochrome P450 Oxidoreductase	Protein Coding	1
6	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
7	SLC28A1	Solute Carrier Family 28 Member 1	Protein Coding	1
8	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
9	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	1
10	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
11	SLC22A6	Solute Carrier Family 22 Member 6	Protein Coding	1
12	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	1
13	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
14	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
15	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
16	SLC22A8	Solute Carrier Family 22 Member 8	Protein Coding	1
17	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	1
18	SLC22A11	Solute Carrier Family 22 Member 11	Protein Coding	1
19	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1
20	SLC22A7	Solute Carrier Family 22 Member 7	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coumarin resistance	Enrichment	CYP2A6, CYP2C9	5.21
2	Colchicine resistance	Enrichment	ABCB1	2.83
3	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.83
4	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	2.83
5	Encephalopathy, acute transient	Enrichment	ABCB1	2.83
6	Inflammatory bowel disease 13	Enrichment	ABCB1	2.83
7	Blood group, junior system	Enrichment	ABCG2	2.83
8	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.83
9	Uridine-cytidineuria	Enrichment	SLC28A1	2.83
10	Neurodegeneration, childhood-onset, with progressive microcephaly	Enrichment	DTYMK	2.83
11	Letrozole toxicity	Enrichment	CYP2A6	2.83
12	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	2.53
13	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	2.53
14	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.53
15	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.53
16	Tobacco addiction	Enrichment	CYP2A6	2.23
17	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.79
18	Lipoid congenital adrenal hyperplasia	Enrichment	POR	1.69
19	Lung cancer	Enrichment	CYP2A6	1.34
20	Primary ovarian insufficiency	Enrichment	POR	1.08

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics